Promethazine Symptoms and indications of overdosage with promethazine HCI range from mild depression in the central nervous program and cardiovascular technique to profound hypotension, respiratory melancholy, unconsciousness, and unexpected Demise.
Anticholinergics: Concomitant usage of other agents with anticholinergic Qualities ought to be carried out with warning.
Excessively huge dosages of antihistamines, such as promethazine hydrochloride, in pediatric people may bring about unexpected Demise (see OVERDOSAGE). Hallucinations and convulsions have happened with therapeutic doses and overdoses of promethazine hydrochloride in pediatric people.
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Considering the fact that recurrences of NMS happen to be noted with phenothiazines, the reintroduction of promethazine HCl should be cautiously deemed.
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Decreased Seizure Threshold: Promethazine may well lower seizure threshold. It ought to be made use of with warning in persons with seizure Conditions or in individuals who're making use of concomitant medicines, for instance narcotics or area anesthetics, which may also affect seizure threshold.
Promethazine hydrochloride occurs for a white to faint yellow, virtually odorless, crystalline powder which bit by bit oxidizes and turns blue on extended exposure to air.
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This mixture is suitable for many respiratory difficulties because it proficiently relieves coughs brought on by colds, the flu, or allergy symptoms.
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A review of the consequences of adrenergic medication on ovum transport in rabbits indicated that treatment method with phenylephrine didn't change incidence of pregnancy; the number of implantations was noticeably decreased when significant doses of the drug had been utilised.